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PeptidesRetatrutide
Price range: $89.00 through $249.00
Retatrutide product description — Triple hormone receptor agonist peptide
Research Peptide · Triple Agonist · LY3437943
Retatrutide
An investigational once-weekly triple hormone receptor agonist activating GLP-1, GIP, and Glucagon receptors simultaneously. The highest weight reduction reported in the incretin class. Purity >99% · Double lab tested.
Regulatory status
Not yet FDA approved. Under active Phase 3 clinical investigation (TRIUMPH program). NDA submission expected after 2026 trial readouts — earliest plausible approval window is 2027.
Developer
Eli Lilly · Code: LY3437943
Program
TRIUMPH Phase 3
Phase 3 readouts
Through 2026
Dosing
Once-weekly subcutaneous
Mechanism of action — triple receptor
GLP-1 receptor
Insulin & appetite control
Stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite centrally — the same broad effects as semaglutide.
Insulin & appetite control
Stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite centrally — the same broad effects as semaglutide.
GIP receptor
Augmented glucose control
Amplifies glucose-dependent insulin release; also influences adipose tissue and central pathways relevant to body weight regulation.
Augmented glucose control
Amplifies glucose-dependent insulin release; also influences adipose tissue and central pathways relevant to body weight regulation.
Glucagon receptor
Energy expenditure & lipolysis
Raises basal energy expenditure and promotes lipolysis — the key differentiator from dual agonists like tirzepatide, driving superior weight loss.
Energy expenditure & lipolysis
Raises basal energy expenditure and promotes lipolysis — the key differentiator from dual agonists like tirzepatide, driving superior weight loss.
Clinical trial evidence
Phase 2 — Obesity (NEJM, 2023)
Participants on 12 mg weekly dose at 48 weeks — the highest weight reduction reported for any agent in the GLP-1 class at the time.
24.2% body weight loss
12 mg weekly · 48 weeks
12 mg weekly · 48 weeks
TRIUMPH-4 — Knee Osteoarthritis (Dec 2025)
Phase 3 readout in adults with obesity/overweight and knee osteoarthritis. Showed substantial reductions in both body weight and osteoarthritis pain scores.
~28.7% weight loss
Significant pain reduction
Significant pain reduction
Phase 3 — Type 2 Diabetes (Mar 2026)
Demonstrated significant reductions in HbA1c and body weight in adults with type 2 diabetes.
HbA1c reduction
Significant weight loss
Significant weight loss
Ongoing TRIUMPH studies
Active trials in obstructive sleep apnea, chronic low back pain, cardiovascular & renal outcomes, and metabolic liver disease (MASLD).
Adverse effects & safety
Adverse-effect profile is broadly consistent with the GLP-1 class — gastrointestinal symptoms predominate, particularly during dose escalation: nausea, vomiting, diarrhea, and constipation.
Notable signal: dysesthesia (skin tingling, sensitivity, altered tactile sensation) — reported in ~21% of TRIUMPH-4 participants on the 12 mg dose. Most events were mild; further characterization is ongoing in Phase 3. Cardiovascular and pancreatic safety will be evaluated through the full Phase 3 dataset.
| Size | 10mg, 20mg, 5mg |
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All Vital Tides peptides are manufactured under strict quality control and independently verified for purity and molecular identity. For research and laboratory use only. Not for human consumption.
Certificate of Analysis available upon request.
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