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PeptidesRetatrutide
Price range: $89.00 through $249.00
Retatrutide research peptide (LY3437943) is a synthetic triple-receptor agonist supplied by Vital Tides for controlled in-vitro laboratory research. It is used to study GIP, GLP-1, and glucagon receptor signaling and is available in 5 mg, 10 mg, and 20 mg vial sizes.
Research Use Only: This product is intended solely for laboratory research and analytical purposes. Not for human or veterinary use.
Retatrutide product description — Triple hormone receptor agonist peptide
Retatrutide Research Peptide
What Is Retatrutide?
Retatrutide research peptide, also known as LY3437943, is a synthetic compound designed for controlled laboratory research. It acts at three receptor types: GIP, GLP-1, and glucagon receptors. This profile allows researchers to study several signaling pathways with one compound.
Vital Tides Peptides offers retatrutide for research in 5 mg, 10 mg, and 20 mg vial sizes. Each vial is intended only for qualified laboratory and analytical work.
Retatrutide is investigational. It is not an FDA-approved medicine and is not intended for human or veterinary use.
Retatrutide Compound Information
| Attribute | Vital Tides Peptides product information |
| Compound name | Retatrutide |
| Research identifier | LY3437943 / LY-3437943 |
| CAS number | 2381089-83-2 |
| Compound class | Synthetic triple-receptor agonist peptide |
| Research targets | GIPR, GLP-1R, and GCGR |
| Available sizes | 5 mg, 10 mg, and 20 mg |
| Product form | Lyophilized research material |
| Intended use | Controlled laboratory research only |
| Regulatory status | Investigational; not FDA-approved |
Mechanism of action
Retatrutide is designed to act as an agonist at GIPR, GLP-1R, and GCGR. Researchers may examine:
- Insulin & appetite control
Stimulates insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite centrally — the same broad effects as semaglutide.
- Augmented glucose control
Amplifies glucose-dependent insulin release; also influences adipose tissue and central pathways relevant to body weight regulation.
- Energy expenditure & lipolysis
Raises basal energy expenditure and promotes lipolysis — the key differentiator from dual agonists like tirzepatide, driving superior weight loss.
Research Applications & Areas of Interest
The Vital Tides Peptides retatrutide research peptide is studied in non-clinical models involving multi-receptor and metabolic signaling. Its activity at three receptor targets supports comparisons between single-, dual-, and triple-agonist research models.
Energy-Balance Research
In non-clinical models, this metabolic research peptide may be studied in relation to:
- Food-intake and satiety-related signaling
- Energy-expenditure pathways
- Body-composition measurements
- Comparative single-, dual-, and triple-agonist activity
Metabolic Pathway Studies
Researchers may use the retatrutide research compound to examine:
- Glucose-response pathways
- Insulin-related receptor signaling
- Lipid handling and oxidation pathways
- Liver lipid measurements in experimental models
Hormonal Pathway Research
Retatrutide for research may help scientists explore how GIPR, GLP-1R, and GCGR signals interact across cell and animal models. Areas of interest include signaling in pancreatic, liver, adipose, and central nervous system models.
Research note: These topics describe in-vitro, animal, and other non-clinical research. They are not consumer benefits, treatment claims, or evidence that this product is safe or effective for human use.
Quality You Can Verify
Current Retatrutide 5 mg Sample
| Sample detail | Reported information |
| Sample ID | SPL-2691 |
| Submitted product | Retatrutide 5 mg, one vial |
| COA publication date | January 6, 2026 |
| Testing source | Independent laboratory report |
Full QC Panel
| QC measurement | Reported result |
| Assay | 5.633 mg |
| Purity | 99.656% |
| Identity by retention time | 1.01, as reported |
| Identity by spectral analysis | 1000, as reported |
| Coelution control | 1000, as reported |
| System suitability | 0.9% RSD |
The results above apply to submitted sample SPL-2691.
Certificate of Analysis
| Size | 10mg, 20mg, 5mg |
|---|---|
| Compound Name | Retatrutide |
| Research Designation | LY3437943 |
| Compound Type | Synthetic peptide |
| Molecular Formula | C221H342N46O68 |
| Molecular Weight | Approx. 4,731 g/mol* |
| Purity | 99% |
| Appearance | Lyophilized powder* |
| Concentration | Not applicable to dry powder; see product specifications* |
| Form | Lyophilized peptide |
| Available Sizes | 5 mg, 10 mg, 20 mg* |
| Research Use | Research Use |
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