Premium research-grade peptide. Purity > 99%. Double lab tested. USA based testing.
PeptidesTesamorelin
Price range: $79.00 through $119.00
Tesamorelin product description — Synthetic GHRH analog peptide
Tesamorelin
A synthetic 44-amino-acid analog of human growth hormone-releasing hormone (GHRH), modified for extended half-life. Stimulates the pituitary’s own GH release in a physiologic, pulsatile pattern. Purity >99% · Double lab tested.
Regulatory status & approval
FDA approved November 2010 for reduction of excess abdominal fat in adults with HIV-associated lipodystrophy. In March 2025, the FDA approved a new weekly-reconstitution formulation (Egrifta WR / F8), bioequivalent to the original. Not indicated for general weight loss.
Mechanism of action — upstream pituitary stimulation
Pituitary stimulation
Binds GHRH receptors on somatotroph cells of the anterior pituitary, triggering endogenous growth hormone release in the body’s natural pulsatile rhythm — preserving negative-feedback control.
GH-driven tissue effects
Elevated GH acts on adipose, muscle, and other tissues. Because tesamorelin acts upstream rather than supplying exogenous GH, it preserves the normal pulsatile pattern and regulatory feedback loop.
Visceral fat reduction
GH stimulates IGF-1 synthesis in the liver. The predominant clinically observable effect is reduction of visceral adipose tissue — the basis for the approved HIV-lipodystrophy indication.
Clinical trial evidence
vs. placebo · 26 weeks
Triglyceride improvement
Adverse effects & safety
Most commonly reported adverse reactions: arthralgia (joint pain), injection-site reactions, pain in the extremities, peripheral edema, and myalgia.
Hypersensitivity signal: anti-tesamorelin IgG antibodies detected in ~85% of patients who developed hypersensitivity reactions, with cross-reactivity to endogenous GHRH in ~60% of antibody-positive patients. Contraindicated in disruption of the hypothalamic-pituitary axis, active malignancy, pregnancy, and hypersensitivity to the drug or excipients. Not recommended in children with open or closed bone growth plates. Long-term cardiovascular safety has not been fully characterized.
| Size | 10mg, 5mg |
|---|
Related products
-
Peptides
BPC-157
Price range: $49.00 through $79.00 Select options This product has multiple variants. The options may be chosen on the product page -
Peptides
Semaglutide
Price range: $79.00 through $229.00 Select options This product has multiple variants. The options may be chosen on the product page -
Peptides
Retatrutide
Price range: $89.00 through $249.00 Select options This product has multiple variants. The options may be chosen on the product page
Reviews
There are no reviews yet.